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Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. bioRxiv [Preprint]. 2024 Jun 13:2023.03.28.534324. doi: 10.1101/2023.03.28.534324. PMID: 37034750
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults. Alzheimers Res Ther. 2024 Jun 8;16(1):124. doi: 10.1186/s13195-024-01486-9. PMID: 38851772
A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv [Preprint]. 2024 Jun 3:2024.06.01.24308050. doi: 10.1101/2024.06.01.24308050. PMID: 38883742
Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome. Sci Rep. 2024 May 29;14(1):12334. doi: 10.1038/s41598-024-61962-y. PMID: 38811657
Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings. Acta Neuropathol. 2024 May 27;147(1):92. doi: 10.1007/s00401-024-02743-9. PMID: 38801558
Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. medRxiv [Preprint]. 2024 May 15:2024.05.15.24307354. doi: 10.1101/2024.05.15.24307354. PMID: 38798514
Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles. J Neurosci. 2024 May 15;44(20):e2366232024. doi: 10.1523/JNEUROSCI.2366-23.2024. PMID: 38561226
A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024 May 9;6(3):fcae157. doi: 10.1093/braincomms/fcae157. eCollection 2024. PMID: 38764776
The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306724. doi: 10.1101/2024.05.01.24306724. PMID: 38746307
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. Lancet Neurol. 2024 May;23(5):500-510. doi: 10.1016/S1474-4422(24)00084-X. PMID: 38631766
Cognitive and functional performance and plasma biomarkers of early Alzheimer’s disease in Down syndrome. Alzheimers Dement (Amst). 2024 Apr 14;16(2):e12582. doi: 10.1002/dad2.12582. eCollection 2024 Apr-Jun. PMID: 38623384
Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer’s disease. Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21. PMID: 38380866
A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease. bioRxiv [Preprint]. 2024 Mar 14:2024.03.12.584646. doi: 10.1101/2024.03.12.584646. PMID: 38559257
Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue. ACS Cent Sci. 2023 Dec 21;10(1):104-121. doi: 10.1021/acscentsci.3c00592. eCollection 2024 Jan 24. PMID: 38292607
Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimers Dement. 2023 Dec;19(12):5755-5764. doi: 10.1002/alz.13382. Epub 2023 Jul 12. PMID: 37438872
Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2212954119. doi: 10.1073/pnas.2212954119. Epub 2022 Nov 7. PMID: 36343257
Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 Jul;15(3):101278. doi: 10.1016/j.dhjo.2022.101278. Epub 2022 Feb 17. PMID: 35256308
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 Jun 23;185(13):2213-2233.e25. doi: 10.1016/j.cell.2022.05.017. PMID: 35750033
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Cell Rep. 2022 Jun 14;39(11):110961. doi: 10.1016/j.celrep.2022.110961. PMID: 35705056
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease. Geroscience. 2022 Jun;44(3):1525-1550. doi: 10.1007/s11357-022-00580-w. Epub 2022 May 19. PMID: 35585302
Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 Jun;18(6):1203-1234. doi: 10.1002/alz.12463. Epub 2021 Nov 10. PMID: 34757693
Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022 May 25;14(1):e12324. doi: 10.1002/dad2.12324. eCollection 2022. PMID: 35634535
Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer’s continuum. Sleep Adv. 2022 May 5;3(1):zpac013. doi: 10.1093/sleepadvances/zpac013. eCollection 2022. PMID: 35669316
Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. J Neurodev Disord. 2022 Mar 23;14(1):22. doi: 10.1186/s11689-022-09435-z. PMID: 35321660
Primitive Reflexes and Dementia in Adults With Down Syndrome. Neurol Clin Pract. 2022 Feb;12(1):6-13. doi: 10.1212/CPJ.0000000000001135. PMID: 36157622
Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer’s Disease in People with Down Syndrome. J Alzheimers Dis. 2022;85(1):153-165. doi: 10.3233/JAD-210572. PMID: 34776436
Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities. J Intellect Disabil Res. 2021 Dec;65(12):1085-1096. doi: 10.1111/jir.12901. Epub 2021 Nov 16.PMID: 34786786
Alzheimer’s disease associated with Down syndrome: a genetic form of dementia.Lancet Neurol. 2021 Nov;20(11):930-942. doi: 10.1016/S1474-4422(21)00245-3.PMID: 34687637
Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain Sci. 2021 Aug 25;11(9):1128. doi: 10.3390/brainsci11091128.PMID: 34573150
Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease. Front Aging Neurosci. 2021 Aug 13;13:728739. doi: 10.3389/fnagi.2021.728739. eCollection 2021.PMID: 34489686
Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study. Lancet Neurol. 2021 Aug;20(8):605-614. doi: 10.1016/S1474-4422(21)00129-0.PMID: 34302785
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease. Nat Genet. 2021 Aug;53(8):1143-1155. doi: 10.1038/s41588-021-00894-z. Epub 2021 Jul 8.PMID: 34239132
APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All.JAMA Neurol. 2021 Aug 1;78(8):913-915. doi: 10.1001/jamaneurol.2021.1649.PMID: 34228117
Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain.J Neurosci. 2021 Jun 9;41(23):5124-5133. doi:10.1523/JNEUROSCI.0361-21.2021.Epub 2021 May 5.PMID: 33952632
Neuropathology of Aging in Cats and its Similarities to Human Alzheimer’s Disease. Front Aging. 2021 Jun 7;2:684607. doi: 10.3389/fragi.2021.684607. eCollection 2021. PMID: 35822024
Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer’s disease.Alzheimers Dement (Amst). 2021 May 2;13(1):e12184. doi: 10.1002/dad2.12184. eCollection 2021.PMID: 33969175
Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer’s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28;10(9):1907. doi: 10.3390/jcm10091907.PMID: 33924960
Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021;5(3-4):99-129. doi: 10.3233/trd-200090. Epub 2021 Apr 15.PMID: 34268067
Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O’Bryant S; Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). J Alzheimers Dis. 2021;79(2):671-681. doi: 10.3233/JAD-201167.PMID: 33337378
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. Prog Neurobiol. 2021 Jan;196:101892. doi: 10.1016/j.pneurobio.2020.101892. Epub 2020 Aug 11.PMID: 32795489
A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. J Intellect Disabil Res. 2020 Dec;64(12):934-945. doi: 10.1111/jir.12784. Epub 2020 Sep 30. PMID: 32996650
Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 Dec;88(6):1165-1177. doi: 10.1002/ana.25905. Epub 2020 Oct 9. PMID: 32944999
Longitudinal assessment of dementia measures in Down syndrome. Alzheimers Dement (Amst). 2020 Nov 14;12(1):e12075. doi: 10.1002/dad2.12075. eCollection 2020. PMID: 33225040
The AT(N) framework for Alzheimer’s disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020 Oct 27;12(1):e12062. doi: 10.1002/dad2.12062. eCollection 2020. PMID: 33134477
Distribution of microglial phenotypes as a function of age and Alzheimer’s disease neuropathology in the brains of people with Down syndrome. Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12113. doi: 10.1002/dad2.12113. eCollection 2020. PMID: 33088896
Feasibility of dual-task gait to estimate Alzheimer’s related cognitive decline in Down syndrome. Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA.Alzheimers Dement (Amst). 2020 Aug 25;12(1):e12092. doi: 10.1002/dad2.12092. eCollection 2020.PMID: 32875058
The Alzheimer’s Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020 Aug 3;12(1):e12065. doi: 10.1002/dad2.12065. eCollection 2020. PMID: 32775597
Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV. Ann Clin Transl Neurol. 2020 Jul;7(7):1166-1173. doi: 10.1002/acn3.51097. Epub 2020 Jul 3. PMID: 32619341
Further understanding the connection between Alzheimer’s disease and Down syndrome. Alzheimers Dement. 2020 Jul;16(7):1065-1077. doi: 10.1002/alz.12112. Epub 2020 Jun 16. PMID: 32544310
Proteomic profiles for Alzheimer’s disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020 Jun 30;12(1):e12039. doi: 10.1002/dad2.12039. eCollection 2020. PMID: 32626817
Biomarkers in Down syndrome can help us understand Alzheimer’s disease. Lancet. 2020 Jun 27;395(10242):1951-1953. doi: 10.1016/S0140-6736(20)30916-8. PMID: 32593327
APOE genotype-dependent pharmacogenetic responses to rapamycin for prAPOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer’s disease. Neurobiol Dis. 2020 Jun;139:104834. doi: 10.1016/j.nbd.2020.104834. Epub 2020 Mar 12. PMID: 32173556
Metabolic correlates of prevalent mild cognitive impairment and Alzheimer’s disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020 Apr 5;12(1):e12028. doi: 10.1002/dad2.12028. eCollection 2020. PMID: 32258359
Brain insulin resistance triggers early onset Alzheimer disease in Down sBrain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020 Apr;137:104772. doi: 10.1016/j.nbd.2020.104772. Epub 2020 Jan 24. PMID: 31987911
Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. Front Neurosci. 2019 Nov 5;13:1189. doi: 10.3389/fnins.2019.01189. eCollection 2019. PMID: 31749679
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3181-3194. doi: 10.1016/j.bbadis.2018.07.005. Epub 2018 Jul 5. PMID: 29981845
Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathol Commun. 2017 Dec 1;5(1):93. doi: 10.1186/s40478-017-0499-4. PMID: 29195510
Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017 Aug 22;7(14):3573-3584. doi: 10.7150/thno.20621. eCollection 2017. PMID: 28912896
Commentary: Building the Older Adult Fall Prevention Movement – Steps and Lessons Learned. Front Public Health. 2016 Dec 22;4:277. doi: 10.3389/fpubh.2016.00277. eCollection 2016. PMID: 28066756
Down syndrome individuals with Alzheimer’s disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer’s disease. Neurobiol Aging. 2015 Sep;36(9):2468-74. doi: 10.1016/j.neurobiolaging.2015.05.016. Epub 2015 May 30. PMID: 26103884
Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? J Parkinsons Dis Alzheimers Dis. 2014 Dec 8;1(1):7. doi: 10.13188/2376-922x.1000004. PMID: 25594074
A canine model of human aging and Alzheimer’s disease. Biochim Biophys Acta. 2013 Sep;1832(9):1384-9. doi: 10.1016/j.bbadis.2013.03.016. Epub 2013 Mar 23. PMID: 23528711
Alzheimer’s Disease in Down Syndrome. Eur J Neurodegener Dis. 2012 Dec;1(3):353-364. PMID: 25285303
Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011 Dec;9(4):651-61. doi: 10.2174/157015911798376217. PMID: 22654723
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener. 2010 Dec 13;5:57. doi: 10.1186/1750-1326-5-57. PMID: 21144050
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec;44(12):752-9. doi: 10.1016/j.exger.2009.08.012. Epub 2009 Sep 6. PMID: 19735717
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec;15(4):685-707. doi: 10.3233/jad-2008-15413. PMID: 19096165
Alzheimer’s disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci. 2007 Nov 14;27(46):12721-31. doi: 10.1523/JNEUROSCI.3201-07.2007. PMID: 18003852
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