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Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. Thorwald M, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O’Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. bioRxiv [Preprint]. 2024 Jun 13:2023.03.28.534324. doi: 10.1101/2023.03.28.534324. PMID: 37034750

Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults. Lohman T, Kapoor A, Engstrom AC, Shenasa F, Alitin JPM, Gaubert A, Rodgers KE, Bradford D, Mather M, Han SD, Head E, Sordo L, Thayer JF, Nation DA. Alzheimers Res Ther. 2024 Jun 8;16(1):124. doi: 10.1186/s13195-024-01486-9. PMID: 38851772

A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E; Alzheimer Biomarker Consortium – Down Syndrome. medRxiv [Preprint]. 2024 Jun 3:2024.06.01.24308050. doi: 10.1101/2024.06.01.24308050. PMID: 38883742

Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome. Lao P, Edwards N, Flores-Aguilar L, Alshikho M, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian BT, Mapstone M, Handen B, Zimmerman ME, Gutierrez J, Wilcock D, Head E, Brickman AM. Sci Rep. 2024 May 29;14(1):12334. doi: 10.1038/s41598-024-61962-y. PMID: 38811657

Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings. Granholm AE, Englund E, Gilmore A, Head E, Yong WH, Perez SE, Guzman SJ, Hamlett ED, Mufson EJ. Acta Neuropathol. 2024 May 27;147(1):92. doi: 10.1007/s00401-024-02743-9. PMID: 38801558

Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein H, Mettenburg JM, Yong W, Head E, Ikonomovic M, Ibrahim T, Kofler J; Alzheimer’s Biomarker Consortium on Down syndrome study. medRxiv [Preprint]. 2024 May 15:2024.05.15.24307354. doi: 10.1101/2024.05.15.24307354. PMID: 38798514

Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles. Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, van Rooyen HY, Perpich JA, McCarty K, Meacham B, Smiley J, Bembenek Bailey SA, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. J Neurosci. 2024 May 15;44(20):e2366232024. doi: 10.1523/JNEUROSCI.2366-23.2024. PMID: 38561226

A pathway linking pulse pressure to dementia in adults with Down syndrome. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. Brain Commun. 2024 May 9;6(3):fcae157. doi: 10.1093/braincomms/fcae157. eCollection 2024. PMID: 38764776

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults. Lohman T, Shenasa F, Sible I, Kapoor A, Engstrom AC, Dutt S, Head E, Sordo L, M Alitin JP, Gaubert A, Nguyen A, Nation DA. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306724. doi: 10.1101/2024.05.01.24306724. PMID: 38746307

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer’s disease: a cross-sectional study. Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM; Alzheimer’s Biomarker Consortium-Down syndrome; Dominantly Inherited Alzheimer Network. Lancet Neurol. 2024 May;23(5):500-510. doi: 10.1016/S1474-4422(24)00084-X. PMID: 38631766

Cognitive and functional performance and plasma biomarkers of early Alzheimer’s disease in Down syndrome. Schworer EK, Handen BL, Petersen M, O’Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL; Alzheimer Biomarker Consortium‐Down Syndrome. Alzheimers Dement (Amst). 2024 Apr 14;16(2):e12582. doi: 10.1002/dad2.12582. eCollection 2024 Apr-Jun. PMID: 38623384

Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer’s disease. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer’s Disease Genetic Consortium (ADGC); Alzheimer’s Biomarkers Consortium‐Down Syndrome (ABC‐DS). Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21. PMID: 38380866

A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease.Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Finkbeiner S, Head E, Liu Y, Jiang P. bioRxiv [Preprint]. 2024 Mar 14:2024.03.12.584646. doi: 10.1101/2024.03.12.584646. PMID: 38559257

Down Syndrome Biobank Consortium: A perspective.Aldecoa I, Barroeta I, Carroll SL, Fortea J, Gilmore A, Ginsberg SD, Guzman SJ, Hamlett ED, Head E, Perez SE, Potter H, Molina-Porcel L, Raha-Chowdhury R, Wisniewski T, Yong WH, Zaman S, Ghosh S, Mufson EJ, Granholm AC. Alzheimers Dement. 2024 Mar;20(3):2262-2272. doi: 10.1002/alz.13692. Epub 2024 Jan 25. PMID: 38270275
Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome.DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O’Bryant S, Yassa MA. Alzheimers Dement (Amst). 2024 Feb 12;16(1):e12542. doi: 10.1002/dad2.12542. eCollection 2024 Jan-Mar. PMID: 38348178

Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue. Kreutzer AG, Parrocha CMT, Haerianardakani S, Guaglianone G, Nguyen JT, Diab MN, Yong W, Perez-Rosendahl M, Head E, Nowick JS. ACS Cent Sci. 2023 Dec 21;10(1):104-121. doi: 10.1021/acscentsci.3c00592. eCollection 2024 Jan 24. PMID: 38292607

Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O’Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E; Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS) investigators. Alzheimers Dement. 2023 Dec;19(12):5755-5764. doi: 10.1002/alz.13382. Epub 2023 Jul 12. PMID: 37438872

Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O’Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. medRxiv [Preprint]. 2023 Nov 30:2023.11.28.23298693. doi: 10.1101/2023.11.28.23298693. PMID: 38076904
Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old. Sordo L, Qian T, Bukhari SA, Nguyen KM, Woodworth DC, Head E, Kawas CH, Corrada MM, Montine TJ, Sajjadi SA. Acta Neuropathol. 2023 Sep;146(3):415-432. doi: 10.1007/s00401-023-02606-9. Epub 2023 Jun 29. PMID: 37382680
Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, Head E, Nation DA. Neurobiol Aging. 2023 Aug;128:43-48. doi: 10.1016/j.neurobiolaging.2023.04.004. Epub 2023 Apr 14. PMID: 37156179
Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial. Yoo HJ, Nashiro K, Min J, Cho C, Mercer N, Bachman SL, Nasseri P, Dutt S, Porat S, Choi P, Zhang Y, Grigoryan V, Feng T, Thayer JF, Lehrer P, Chang C, Stanley JA, Head E, Rouanet J, Marmarelis VZ, Narayanan S, Wisnowski J, Nation DA, Mather M. Sci Data. 2023 Jul 29;10(1):503. doi: 10.1038/s41597-023-02396-5. PMID: 37516756
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s Disease. Miyoshi E, Morabito S, Henningfield CM, Rahimzadeh N, Kiani Shabestari S, Das S, Michael N, Reese F, Shi Z, Cao Z, Scarfone V, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Head E, Green KN, Swarup V. bioRxiv [Preprint]. 2023 Jul 26:2023.07.24.550282. doi: 10.1101/2023.07.24.550282. PMID: 37546983
Amyloid futures in the expanding pathology of brain aging and dementia. Thorwald MA, Silva J, Head E, Finch CE. Alzheimers Dement. 2023 Jun;19(6):2605-2617. doi: 10.1002/alz.12896. Epub 2022 Dec 19. PMID: 36536382
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer’s disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. Alzheimers Dement. 2023 May;19(5):2095-2116. doi: 10.1002/alz.12835. Epub 2022 Nov 12. PMID: 36370135
Differential involvement of hippocampal subfields in the relationship between Alzheimer’s pathology and memory interference in older adults. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. Alzheimers Dement (Amst). 2023 Apr 5;15(2):e12419. doi: 10.1002/dad2.12419. eCollection 2023 Apr-Jun. PMID: 37035460
Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. Transl Psychiatry. 2023 Apr 4;13(1):111. doi: 10.1038/s41398-023-02419-0. PMID: 37015911
Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. Mol Syndromol. 2023 Apr;14(2):89-100. doi: 10.1159/000526021. Epub 2022 Nov 11. PMID: 37064334
Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Min J, Rouanet J, Martini AC, Nashiro K, Yoo HJ, Porat S, Cho C, Wan J, Cole SW, Head E, Nation DA, Thayer JF, Mather M. Sci Rep. 2023 Mar 9;13(1):3967. doi: 10.1038/s41598-023-30167-0. PMID: 36894565
Timing of Alzheimer’s Disease by Intellectual Disability Level in Down Syndrome. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B; Alzheimer Biomarker Consortium-Down Syndrome. J Alzheimers Dis. 2023;95(1):213-225. doi: 10.3233/JAD-230200. PMID: 37482997
Weight Loss and Alzheimer’s Disease in Down Syndrome. Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, Christian BT, Head E, Mapstone M, Lai F, Krinsky-McHale S, Zaman S, Ances BM, Lee JH, Hartley SL; Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium. J Alzheimers Dis. 2023;91(3):1215-1227. doi: 10.3233/JAD-220865. PMID: 36565120
Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM; Alzheimer’s Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network. Lancet Neurol. 2023 Jan;22(1):55-65. doi: 10.1016/S1474-4422(22)00408-2. PMID: 36517172

Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2212954119. doi: 10.1073/pnas.2212954119. Epub 2022 Nov 7. PMID: 36343257

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults. Sible IJ, Yew B, Jang JY, Alitin JPM, Li Y, Gaubert A, Nguyen A, Dutt S, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Rodgers KE, Sturm VE, Head E, Martini A, Nation DA. Sci Rep. 2022 Oct 13;12(1):17197. doi: 10.1038/s41598-022-20627-4. PMID: 36229634
Probing the proteome to explore potential correlates of increased Alzheimer’s-related cerebrovascular disease in adults with Down syndrome. Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, O’Bryant S, Brickman AM. Alzheimers Dement. 2022 Oct;18(10):1744-1753. doi: 10.1002/alz.12627. Epub 2022 Feb 24. PMID: 35212182
Exploring the role of sex differences in Alzheimer’s disease pathogenesis in Down syndrome. Andrews EJ, Martini AC, Head E. Front Neurosci. 2022 Aug 12;16:954999. doi: 10.3389/fnins.2022.954999. eCollection 2022. PMID: 36033603
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease. Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. Cell Stem Cell. 2022 Jul 7;29(7):1135-1153.e8. doi: 10.1016/j.stem.2022.06.007. PMID: 35803230
Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome. Martini AC, Gross TJ, Head E, Mapstone M. Neuron. 2022 Jul 6;110(13):2063-2079. doi: 10.1016/j.neuron.2022.04.001. Epub 2022 Apr 25. PMID: 35472307
Commentary on Oeckl et al., “Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181”. Head E, Zetterberg H. Ann Neurol. 2022 Jul;92(1):3-5. doi: 10.1002/ana.26414. Epub 2022 Jun 2. PMID: 35599543

Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N; ABC-DS Group. Disabil Health J. 2022 Jul;15(3):101278. doi: 10.1016/j.dhjo.2022.101278. Epub 2022 Feb 17. PMID: 35256308

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Cell. 2022 Jun 23;185(13):2213-2233.e25. doi: 10.1016/j.cell.2022.05.017. PMID: 35750033

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. Cell Rep. 2022 Jun 14;39(11):110961. doi: 10.1016/j.celrep.2022.110961. PMID: 35705056

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease. Macciardi F, Giulia Bacalini M, Miramontes R, Boattini A, Taccioli C, Modenini G, Malhas R, Anderlucci L, Gusev Y, Gross TJ, Padilla RM, Fiandaca MS, Head E, Guffanti G, Federoff HJ, Mapstone M. Geroscience. 2022 Jun;44(3):1525-1550. doi: 10.1007/s11357-022-00580-w. Epub 2022 May 19. PMID: 35585302

Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. Alzheimers Dement. 2022 Jun;18(6):1203-1234. doi: 10.1002/alz.12463. Epub 2021 Nov 10. PMID: 34757693

Joint-label fusion brain atlases for dementia research in Down syndrome. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB; Alzheimer’s Biomarkers Consortium. Alzheimers Dement (Amst). 2022 May 25;14(1):e12324. doi: 10.1002/dad2.12324. eCollection 2022. PMID: 35634535

Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer’s continuum. Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Diana Rosas H, Silverman W, Lott IT, Schupf N, Brickman AM. Sleep Adv. 2022 May 5;3(1):zpac013. doi: 10.1093/sleepadvances/zpac013. eCollection 2022. PMID: 35669316

Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. Baumer NT, Becker ML, Capone GT, Egan K, Fortea J, Handen BL, Head E, Hendrix JE, Litovsky RY, Strydom A, Tapia IE, Rafii MS. J Neurodev Disord. 2022 Mar 23;14(1):22. doi: 10.1186/s11689-022-09435-z. PMID: 35321660

Primitive Reflexes and Dementia in Adults With Down Syndrome. Harp J, Koehl L, Van Pelt K, Head E, Jicha G, Robertson W, Lightner D, Lott I, Schmitt F. Neurol Clin Pract. 2022 Feb;12(1):6-13. doi: 10.1212/CPJ.0000000000001135. PMID: 36157622

Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer’s Disease in People with Down Syndrome. DiProspero ND, Keator DB, Phelan M, van Erp TGM, Doran E, Powell DK, Van Pelt KL, Schmitt FA, Head E, Lott IT, Yassa MA. J Alzheimers Dis. 2022;85(1):153-165. doi: 10.3233/JAD-210572. PMID: 34776436

Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities. Wallace ER, Harp JP, Van Pelt KL, Koehl LM, Caban-Holt AM, Anderson-Mooney AJ, Jicha GA, Lightner DD, Robertson WC, Head E, Schmitt FA.J Intellect Disabil Res. 2021 Dec;65(12):1085-1096. doi: 10.1111/jir.12901. Epub 2021 Nov 16.PMID: 34786786

Alzheimer’s disease associated with Down syndrome: a genetic form of dementia.Fortea J, Zaman SH, Hartley S, Rafii MS, Head E, Carmona-Iragui M.Lancet Neurol. 2021 Nov;20(11):930-942. doi: 10.1016/S1474-4422(21)00245-3.PMID: 34687637

Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Harp JP, Koehl LM, Pelt KLV, Hom CL, Doran E, Head E, Lott IT, Schmitt FA.Brain Sci. 2021 Aug 25;11(9):1128. doi: 10.3390/brainsci11091128.PMID: 34573150

Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease. Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD.Front Aging Neurosci. 2021 Aug 13;13:728739. doi: 10.3389/fnagi.2021.728739. eCollection 2021.PMID: 34489686

Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study. Carmona-Iragui M, Alcolea D, Barroeta I, Videla L, Muñoz L, Van Pelt KL, Schmitt FA, Lightner DD, Koehl LM, Jicha G, Sacco S, Mircher C, Pape SE, Hithersay R, Clare ICH, Holland AJ, Nübling G, Levin J, Zaman SH, Strydom A, Rebillat AS, Head E, Blesa R, Lleó A, Fortea J.Lancet Neurol. 2021 Aug;20(8):605-614. doi: 10.1016/S1474-4422(21)00129-0.PMID: 34302785

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease. Morabito S, Miyoshi E, Michael N, Shahin S, Martini AC, Head E, Silva J, Leavy K, Perez-Rosendahl M, Swarup V.Nat Genet. 2021 Aug;53(8):1143-1155. doi: 10.1038/s41588-021-00894-z. Epub 2021 Jul 8.PMID: 34239132

APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All.Lemere CA, Head E, Holtzman DM.JAMA Neurol. 2021 Aug 1;78(8):913-915. doi: 10.1001/jamaneurol.2021.1649.PMID: 34228117

Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain.Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E.J Neurosci. 2021 Jun 9;41(23):5124-5133. doi:10.1523/JNEUROSCI.0361-21.2021.Epub 2021 May 5.PMID: 33952632

Neuropathology of Aging in Cats and its Similarities to Human Alzheimer’s Disease. Sordo L, Martini AC, Houston EF, Head E, Gunn-Moore D. Front Aging. 2021 Jun 7;2:684607. doi: 10.3389/fragi.2021.684607. eCollection 2021. PMID: 35822024

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer’s disease.Aschenbrenner AJ, Baksh RA, Benejam B, Beresford-Webb JA, Coppus A, Fortea J, Handen BL, Hartley S, Head E, Jaeger J, Levin J, Loosli SV, Rebillat AS, Sacco S, Schmitt FA, Thurlow KE, Zaman S, Hassenstab J, Strydom A.Alzheimers Dement (Amst). 2021 May 2;13(1):e12184. doi: 10.1002/dad2.12184. eCollection 2021.PMID: 33969175

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer’s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W.J Clin Med. 2021 Apr 28;10(9):1907. doi: 10.3390/jcm10091907.PMID: 33924960

Opportunities, barriers, and recommendations in down syndrome research. Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS.Transl Sci Rare Dis. 2021;5(3-4):99-129. doi: 10.3233/trd-200090. Epub 2021 Apr 15.PMID: 34268067

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O’Bryant S; Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). J Alzheimers Dis. 2021;79(2):671-681. doi: 10.3233/JAD-201167.PMID: 33337378

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. Prog Neurobiol. 2021 Jan;196:101892. doi: 10.1016/j.pneurobio.2020.101892. Epub 2020 Aug 11.PMID: 32795489

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. Thalman S, Van Pelt KL, Lin AL, Johnson NF, Jicha G, Caban-Holt A, Robertson W, Lightner D, Powell D, Head E, Schmitt F. J Intellect Disabil Res. 2020 Dec;64(12):934-945. doi: 10.1111/jir.12784. Epub 2020 Sep 30. PMID: 32996650

Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. Ann Neurol. 2020 Dec;88(6):1165-1177. doi: 10.1002/ana.25905. Epub 2020 Oct 9. PMID: 32944999

Longitudinal assessment of dementia measures in Down syndrome. Koehl L, Harp J, Van Pelt KL, Head E, Schmitt FA. Alzheimers Dement (Amst). 2020 Nov 14;12(1):e12075. doi: 10.1002/dad2.12075. eCollection 2020. PMID: 33225040

The AT(N) framework for Alzheimer’s disease in adults with Down syndrome. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O’Bryant S. Alzheimers Dement (Amst). 2020 Oct 27;12(1):e12062. doi: 10.1002/dad2.12062. eCollection 2020. PMID: 33134477

Distribution of microglial phenotypes as a function of age and Alzheimer’s disease neuropathology in the brains of people with Down syndrome. Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. Alzheimers Dement (Amst). 2020 Oct 14;12(1):e12113. doi: 10.1002/dad2.12113. eCollection 2020. PMID: 33088896

Feasibility of dual-task gait to estimate Alzheimer’s related cognitive decline in Down syndrome. Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA.Alzheimers Dement (Amst). 2020 Aug 25;12(1):e12092. doi: 10.1002/dad2.12092. eCollection 2020.PMID: 32875058

The Alzheimer’s Biomarker Consortium-Down Syndrome: Rationale and methodology. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W; Alzheimer’s Biomarker Consortium‐Down Syndrome (ABC‐DS). Alzheimers Dement (Amst). 2020 Aug 3;12(1):e12065. doi: 10.1002/dad2.12065. eCollection 2020. PMID: 32775597

Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV. Ellis RJ, Diaz M, Sacktor N, Marra C, Collier AC, Clifford DB, Calcutt N, Fields JA, Heaton RK, Letendre SL; CNS Antiretroviral Therapy Effects Research (CHARTER) Study Group. Ann Clin Transl Neurol. 2020 Jul;7(7):1166-1173. doi: 10.1002/acn3.51097. Epub 2020 Jul 3. PMID: 32619341

Further understanding the connection between Alzheimer’s disease and Down syndrome. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. Alzheimers Dement. 2020 Jul;16(7):1065-1077. doi: 10.1002/alz.12112. Epub 2020 Jun 16. PMID: 32544310

Proteomic profiles for Alzheimer’s disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer’s Biomarker Consortium-Down Syndrome (ABC-DS) study. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O’Bryant S; Alzheimer’s Biomarker Consortium – Down Syndrome (ABC‐DS). Alzheimers Dement (Amst). 2020 Jun 30;12(1):e12039. doi: 10.1002/dad2.12039. eCollection 2020. PMID: 32626817

Biomarkers in Down syndrome can help us understand Alzheimer’s disease. Head E, Ances B. Lancet. 2020 Jun 27;395(10242):1951-1953. doi: 10.1016/S0140-6736(20)30916-8. PMID: 32593327

APOE genotype-dependent pharmacogenetic responses to rapamycin for prAPOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer’s disease. Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. Neurobiol Dis. 2020 Jun;139:104834. doi: 10.1016/j.nbd.2020.104834. Epub 2020 Mar 12. PMID: 32173556

Metabolic correlates of prevalent mild cognitive impairment and Alzheimer’s disease in adults with Down syndrome. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators. Alzheimers Dement (Amst). 2020 Apr 5;12(1):e12028. doi: 10.1002/dad2.12028. eCollection 2020. PMID: 32258359

Brain insulin resistance triggers early onset Alzheimer disease in Down sBrain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E. Neurobiol Dis. 2020 Apr;137:104772. doi: 10.1016/j.nbd.2020.104772. Epub 2020 Jan 24. PMID: 31987911

Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. Thalman SW, Powell DK, Ubele M, Norris CM, Head E, Lin AL. Front Neurosci. 2019 Nov 5;13:1189. doi: 10.3389/fnins.2019.01189. eCollection 2019. PMID: 31749679

Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. Hamburg S, Lowe B, Startin CM, Padilla C, Coppus A, Silverman W, Fortea J, Zaman S, Head E, Handen BL, Lott I, Song W, Strydom A. J Neurodev Disord. 2019 Aug 30;11(1):20. doi: 10.1186/s11689-019-9279-8. PMID: 31470792
Alzheimer’s disease in aging Down syndrome. Cohen AD, Head E, Lee JH. Dev Neurobiol. 2019 Jul;79(7):611-612. doi: 10.1002/dneu.22717. PMID: 31545018
Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer’s disease. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. Dev Neurobiol. 2019 Jul;79(7):622-638. doi: 10.1002/dneu.22716. Epub 2019 Aug 26. PMID: 31419370
Neuropathological correlates of amyloid PET imaging in Down syndrome. Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. Dev Neurobiol. 2019 Jul;79(7):750-766. doi: 10.1002/dneu.22713. Epub 2019 Aug 17. PMID: 31379087
Dementia in Down syndrome: unique insights for Alzheimer disease research. Lott IT, Head E. Nat Rev Neurol. 2019 Mar;15(3):135-147. doi: 10.1038/s41582-018-0132-6. PMID: 30733618
Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O’Bryant SE; International Society to Advance Alzheimer’s Research and Treatment, Alzheimer’s Association. Alzheimers Dement. 2019 Feb;15(2):292-312. doi: 10.1016/j.jalz.2018.09.009. Epub 2018 Dec 13. PMID: 30555031
Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. Mol Syndromol. 2019 Jan;9(6):279-286. doi: 10.1159/000494231. Epub 2018 Oct 30. PMID: 30800043
Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer’s Disease. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. J Alzheimers Dis. 2019;67(1):103-112. doi: 10.3233/JAD-180589. PMID: 30452414

Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3181-3194. doi: 10.1016/j.bbadis.2018.07.005. Epub 2018 Jul 5. PMID: 29981845

Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395):eaap8757. doi: 10.1126/science.aap8757. PMID: 29930110
Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Head E, Powell DK, Schmitt FA. Front Aging Neurosci. 2018 Jun 21;10:191. doi: 10.3389/fnagi.2018.00191. eCollection 2018. PMID: 29977201
Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease. Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, Hussaini SA, Marquer C. Cell Rep. 2018 Jun 5;23(10):2967-2975. doi: 10.1016/j.celrep.2018.05.011. PMID: 29874583
Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Brain Pathol. 2018 May;28(3):427-430. doi: 10.1111/bpa.12573. PMID: 29740941
An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. Front Aging Neurosci. 2018 Jan 30;10:7. doi: 10.3389/fnagi.2018.00007. eCollection 2018. PMID: 29441010
Down syndrome, beta-amyloid and neuroimaging. Head E, Helman AM, Powell D, Schmitt FA. Free Radic Biol Med. 2018 Jan;114:102-109. doi: 10.1016/j.freeradbiomed.2017.09.013. Epub 2017 Sep 19. PMID: 28935420
mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. Free Radic Biol Med. 2018 Jan;114:94-101. doi: 10.1016/j.freeradbiomed.2017.08.009. Epub 2017 Aug 12. PMID: 28807816
Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism. Barone E, Arena A, Head E, Butterfield DA, Perluigi M. Free Radic Biol Med. 2018 Jan;114:84-93. doi: 10.1016/j.freeradbiomed.2017.07.009. Epub 2017 Jul 10. PMID: 28705658

Cerebrovascular pathology in Down syndrome and Alzheimer disease. Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. Acta Neuropathol Commun. 2017 Dec 1;5(1):93. doi: 10.1186/s40478-017-0499-4. PMID: 29195510

Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer’s disease. Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinós MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, Bosch B, Lladó A, Rafii MS, Head E, Molinuevo JL, Blesa R, Videla S, Lleó A, Sánchez-Valle R, Fortea J. Alzheimers Dement. 2017 Nov;13(11):1251-1260. doi: 10.1016/j.jalz.2017.03.007. Epub 2017 Apr 29. PMID: 28463681
HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Barone E, Head E, Butterfield DA, Perluigi M. Free Radic Biol Med. 2017 Oct;111:262-269. doi: 10.1016/j.freeradbiomed.2016.10.508. Epub 2016 Nov 10. PMID: 27838436

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. O’Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. Theranostics. 2017 Aug 22;7(14):3573-3584. doi: 10.7150/thno.20621. eCollection 2017. PMID: 28912896

Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. LeVine H 3rd, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. Neurobiol Aging. 2017 Jun;54:163-169. doi: 10.1016/j.neurobiolaging.2017.03.005. Epub 2017 Mar 14. PMID: 28385551
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Tramutola A, Di Domenico F, Barone E, Arena A, Giorgi A, di Francesco L, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. Antioxid Redox Signal. 2017 Mar 1;26(7):280-298. doi: 10.1089/ars.2016.6686. Epub 2016 Oct 26. PMID: 27627691
Translational models for vascular cognitive impairment: a review including larger species. Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, Ihara M, Isaacs JD, Kalaria RN, Lesnik Oberstein SA, Moss MB, Nitzsche B, Rosenberg GA, Rutten JW, Salkovic-Petrisic M, Troen AM. BMC Med. 2017 Jan 25;15(1):16. doi: 10.1186/s12916-017-0793-9. PMID: 28118831
Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The Role of APP. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. J Alzheimers Dis. 2017;56(2):459-470. doi: 10.3233/JAD-160836. PMID: 27983553
Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E. Neurobiol Aging. 2017 Jan;49:86-99. doi: 10.1016/j.neurobiolaging.2016.09.007. Epub 2016 Sep 26. PMID: 27776266

Commentary: Building the Older Adult Fall Prevention Movement – Steps and Lessons Learned. Smith ML, Chaudhary S, Nieb S, Bayakly R, Graham K, Head E. Front Public Health. 2016 Dec 22;4:277. doi: 10.3389/fpubh.2016.00277. eCollection 2016. PMID: 28066756

A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. J Alzheimers Dis. 2016 Oct 4;54(3):1251. doi: 10.3233/JAD-169008. PMID: 27716679
(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia. Lin AL, Powell D, Caban-Holt A, Jicha G, Robertson W, Gold BT, Davis R, Abner E, Wilcock DM, Schmitt FA, Head E. Neuroimage Clin. 2016 Jun 2;11:728-735. doi: 10.1016/j.nicl.2016.06.001. eCollection 2016. PMID: 27330972
Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. Aging Dis. 2016 May 27;7(3):267-77. doi: 10.14336/AD.2015.1020. eCollection 2016 May. PMID: 27330841
Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. Mol Neurodegener. 2016 May 23;11(1):42. doi: 10.1186/s13024-016-0105-4. PMID: 27216421
Cerebrovascular contributions to aging and Alzheimer’s disease in Down syndrome. Wilcock DM, Schmitt FA, Head E. Biochim Biophys Acta. 2016 May;1862(5):909-14. doi: 10.1016/j.bbadis.2015.11.007. Epub 2015 Nov 26. PMID: 26593849
Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. Mol Neurodegener. 2016 Apr 26;11:31. doi: 10.1186/s13024-016-0095-2. PMID: 27112350
Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. Brain Cogn. 2016 Apr;104:48-57. doi: 10.1016/j.bandc.2016.02.007. Epub 2016 Feb 27. PMID: 26930369
Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases. Youssef SA, Capucchio MT, Rofina JE, Chambers JK, Uchida K, Nakayama H, Head E. Vet Pathol. 2016 Mar;53(2):327-48. doi: 10.1177/0300985815623997. Epub 2016 Feb 11. PMID: 26869150
Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer’s Disease Brain and Synthetic Aβ Fibrils. Fosso MY, McCarty K, Head E, Garneau-Tsodikova S, LeVine H 3rd. ACS Chem Neurosci. 2016 Feb 17;7(2):171-6. doi: 10.1021/acschemneuro.5b00266. Epub 2015 Dec 30. PMID: 26682772
A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. J Alzheimers Dis. 2016;52(2):731-45. doi: 10.3233/JAD-151124. PMID: 27031484
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. J Alzheimers Dis. 2016;52(1):359-371. doi: 10.3233/JAD-151105. PMID: 26967221
Aging in Down Syndrome and the Development of Alzheimer’s Disease Neuropathology. Head E, Lott IT, Wilcock DM, Lemere CA. Curr Alzheimer Res. 2016;13(1):18-29. doi: 10.2174/1567205012666151020114607. PMID: 26651341

Down syndrome individuals with Alzheimer’s disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer’s disease. Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Neurobiol Aging. 2015 Sep;36(9):2468-74. doi: 10.1016/j.neurobiolaging.2015.05.016. Epub 2015 May 30. PMID: 26103884

OWNING the EHR and INFORMATION GOVERNANCE at Your Facility. Head E. J AHIMA. 2015 Aug;86(8):24-6. PMID: 26364340
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb;72(2):209-16. doi: 10.1001/jamaneurol.2014.2157. PMID: 25531812
Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer’s disease. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. J Alzheimers Dis. 2015;44(4):1107-20. doi: 10.3233/JAD-141254. PMID: 25391381

Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? Rohn TT, McCarty KL, Love JE, Head E. J Parkinsons Dis Alzheimers Dis. 2014 Dec 8;1(1):7. doi: 10.13188/2376-922x.1000004. PMID: 25594074

Alzheimer’s therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H 3rd, Spires-Jones TL, Catalano SM. PLoS One. 2014 Nov 12;9(11):e111899. doi: 10.1371/journal.pone.0111899. eCollection 2014. PMID: 25390692
Aging in the canine and feline brain. Vite CH, Head E. Vet Clin North Am Small Anim Pract. 2014 Nov;44(6):1113-29. doi: 10.1016/j.cvsm.2014.07.008. Epub 2014 Nov 1. PMID: 25441628
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov;71(11):1394-404. doi: 10.1001/jamaneurol.2014.1491. PMID: 25199842
An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. Free Radic Biol Med. 2014 Nov;76:89-95. doi: 10.1016/j.freeradbiomed.2014.08.006. Epub 2014 Aug 20. PMID: 25151119
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down’s syndrome and Alzheimer’s disease brain. Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. Biochem J. 2014 Oct 15;463(2):177-89. doi: 10.1042/BJ20140772. PMID: 25242166
Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. J Cereb Blood Flow Metab. 2014 Oct;34(10):1637-45. doi: 10.1038/jcbfm.2014.124. Epub 2014 Jul 23. PMID: 25052558
Con: are we ready to translate Alzheimer’s disease-modifying therapies to people with down syndrome? Head E, Schmitt FA. Alzheimers Res Ther. 2014 Sep 12;6(5-8):61. doi: 10.1186/s13195-014-0061-6. eCollection 2014. PMID: 25478026
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. Biochim Biophys Acta. 2014 Jul;1842(7):1144-53. doi: 10.1016/j.bbadis.2014.04.007. Epub 2014 Apr 13. PMID: 24735980
Frontal white matter integrity in adults with Down syndrome with and without dementia. Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. Neurobiol Aging. 2014 Jul;35(7):1562-9. doi: 10.1016/j.neurobiolaging.2014.01.137. Epub 2014 Feb 4. PMID: 24582640
Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. Free Radic Biol Med. 2014 Jun;71:270-280. doi: 10.1016/j.freeradbiomed.2014.03.027. Epub 2014 Mar 25. PMID: 24675226
An outbreak of Candida albicans folliculitis masquerading as Malassezia folliculitis in a prison population. Jalalat S, Hunter L, Yamazaki M, Head E, Kelly B. J Correct Health Care. 2014 Apr;20(2):154-62. doi: 10.1177/1078345813518636. PMID: 24659762
Prevention approaches in a preclinical canine model of Alzheimer’s disease: benefits and challenges. Davis PR, Head E. Front Pharmacol. 2014 Mar 21;5:47. doi: 10.3389/fphar.2014.00047. eCollection 2014. PMID: 24711794
Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer’s disease brain and correlates with neurofibrillary tangle pathology. Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. J Alzheimers Dis. 2014;42(4):1221-7. doi: 10.3233/JAD-132450. PMID: 25024306
Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer’s disease. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. J Alzheimers Dis. 2014;42(3):767-75. doi: 10.3233/JAD-140795. PMID: 24927707
Autoimmune manifestations in the 3xTg-AD model of Alzheimer’s disease. Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. J Alzheimers Dis. 2014;39(1):191-210. doi: 10.3233/JAD-131490. PMID: 24150111

A canine model of human aging and Alzheimer’s disease. Head E. Biochim Biophys Acta. 2013 Sep;1832(9):1384-9. doi: 10.1016/j.bbadis.2013.03.016. Epub 2013 Mar 23. PMID: 23528711

Unusual features in four canine meningiomas. Schöniger S, Woolford L, Jutras L, Head E, de Lahunta A, Summers BA. J Comp Pathol. 2013 Aug-Oct;149(2-3):237-41. doi: 10.1016/j.jcpa.2013.03.003. Epub 2013 May 6. PMID: 23660088
Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: redox proteomics analysis of human brain. Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. Biochim Biophys Acta. 2013 Aug;1832(8):1249-59. doi: 10.1016/j.bbadis.2013.04.013. Epub 2013 Apr 18. PMID: 23603808
Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human down syndrome brains. Kuhn DE, Nuovo GJ, Terry AV Jr, Martin MM, Malana GE, Sansom SE, Pleister AP, Beck WD, Head E, Feldman DS, Elton TS. J Biol Chem. 2013 Feb 8;288(6):4228. doi: 10.1074/jbc.A109.033407. PMID: 23690060
Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. J Cereb Blood Flow Metab. 2013 Feb;33(2):205-14. doi: 10.1038/jcbfm.2012.154. Epub 2012 Nov 14. PMID: 23149553
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. PLoS One. 2013;8(3):e59735. doi: 10.1371/journal.pone.0059735. Epub 2013 Mar 21. PMID: 23555764

Alzheimer’s Disease in Down Syndrome. Head E, Powell D, Gold BT, Schmitt FA. Eur J Neurodegener Dis. 2012 Dec;1(3):353-364. PMID: 25285303

Atorvastatin treatment in a dog preclinical model of Alzheimer’s disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Int J Neuropsychopharmacol. 2012 Aug;15(7):981-7. doi: 10.1017/S1461145711001118. Epub 2011 Jul 18. PMID: 21767440
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer’s disease. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. Neurobiol Aging. 2012 Aug;33(8):1522-32. doi: 10.1016/j.neurobiolaging.2011.03.012. Epub 2011 May 4. PMID: 21546126
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17;79(3):221-8. doi: 10.1212/WNL.0b013e3182605801. Epub 2012 Jun 20. PMID: 22722634
Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N’Dow J, Grigor KM; Edinburgh Urological Cancer Group. BJU Int. 2012 Jun;109(11):1666-73. doi: 10.1111/j.1464-410X.2011.10571.x. Epub 2011 Nov 1. PMID: 22044434
Antioxidants in the canine model of human aging. Dowling AL, Head E. Biochim Biophys Acta. 2012 May;1822(5):685-9. doi: 10.1016/j.bbadis.2011.09.020. Epub 2011 Oct 8. PMID: 22005070
Frontal cortex neuropathology in dementia pugilistica. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. J Neurotrauma. 2012 Apr 10;29(6):1054-70. doi: 10.1089/neu.2011.1957. Epub 2012 Apr 10. PMID: 22017610
BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. Neurobiol Aging. 2012 Mar;33(3):546-54. doi: 10.1016/j.neurobiolaging.2010.03.019. Epub 2010 May 5. PMID: 20447733
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H 3rd, Lott IT, Schmitt FA, Butterfield DA, Head E. Biochim Biophys Acta. 2012 Feb;1822(2):130-8. doi: 10.1016/j.bbadis.2011.10.001. Epub 2011 Oct 8. PMID: 22009041
A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer’s disease. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. J Alzheimers Dis. 2012;32(4):1029-42. doi: 10.3233/JAD-2012-120937. PMID: 22886019
Aging and down syndrome. Head E, Silverman W, Patterson D, Lott IT. Curr Gerontol Geriatr Res. 2012;2012:412536. doi: 10.1155/2012/412536. Epub 2012 Jul 11. PMID: 22844278
Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. Curr Gerontol Geriatr Res. 2012;2012:179318. doi: 10.1155/2012/179318. Epub 2012 May 9. PMID: 22649448
BACE2 expression increases in human neurodegenerative disease. Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. Am J Pathol. 2012 Jan;180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7. PMID: 22074738
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. J Neurochem. 2012 Jan;120(1):135-46. doi: 10.1111/j.1471-4159.2011.07538.x. Epub 2011 Nov 9. PMID: 22004509
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Neurobiol Aging. 2012 Jan;33(1):108-20. doi: 10.1016/j.neurobiolaging.2010.02.008. Epub 2010 Apr 30. PMID: 20434811

Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Martin SB, Dowling AL, Head E. Curr Neuropharmacol. 2011 Dec;9(4):651-61. doi: 10.2174/157015911798376217. PMID: 22654723

Intersectin 1 contributes to phenotypes in vivo: implications for Down’s syndrome. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O’Bryan JP. Neuroreport. 2011 Oct 26;22(15):767-72. doi: 10.1097/WNR.0b013e32834ae348. PMID: 21876463
Neurobiology of the aging dog. Head E. Age (Dordr). 2011 Sep;33(3):485-96. doi: 10.1007/s11357-010-9183-3. Epub 2010 Sep 16. PMID: 20845082
Coenzyme Q10 and cognition in atorvastatin treated dogs. Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. Neurosci Lett. 2011 Aug 26;501(2):92-5. doi: 10.1016/j.neulet.2011.06.054. Epub 2011 Jul 8. PMID: 21763754
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. Am J Med Genet A. 2011 Aug;155A(8):1939-48. doi: 10.1002/ajmg.a.34114. Epub 2011 Jul 7. PMID: 21739598
Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Acta Neuropathol. 2011 May;121(5):571-87. doi: 10.1007/s00401-011-0826-y. Epub 2011 Apr 24. PMID: 21516511
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease. Nat Genet. 2011 May;43(5):436-41. doi: 10.1038/ng.801. Epub 2011 Apr 3. PMID: 21460841
Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer’s disease. Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ. Neurobiol Aging. 2011 Apr;32(4):604-13. doi: 10.1016/j.neurobiolaging.2009.04.008. Epub 2009 May 9. PMID: 19428144
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Pharmacol Res. 2011 Mar;63(3):172-80. doi: 10.1016/j.phrs.2010.12.007. Epub 2010 Dec 27. PMID: 21193043
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer’s disease. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PLoS One. 2011;6(10):e24777. doi: 10.1371/journal.pone.0024777. Epub 2011 Oct 26. PMID: 22046234
Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. J Alzheimers Dis. 2011;23(3):399-409. doi: 10.3233/JAD-2010-101335. PMID: 21116050
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R 3rd, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Mol Neurodegener. 2010 Dec 13; 5:57. PMID: 21144050, DOI: 10.1186/1750-1326-5-57.
Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD; Alzheimer’s Disease Genetics Consortium, Arnold SE, Baldwin CT, Barber R, Beach T, Bigio EH, Bird TD, Boxer A, Burke JR, Cairns N, Carroll SL, Chui HC, Clark DG, Cotman CW, Cummings JL, DeCarli C, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Gearing M, Geschwind DH, Ghetti B, Gilman S, Giordani B, Glass J, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin L-W, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EM, Kowall NW, Lah JJ, Levey AI, Lieberman A, Lopez OL, Mack WJ, Markesbery W, Marson DC, Martiniuk F, Masliah E, McKee AC, Mesulam M, Miller JW, Miller BL, Miller CA, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon W, Quinn JF, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Smith CD, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Woltjer RL, Younkin SG. Arch Neurol. 2010 Dec; 67(12):1473-84. Epub 2010 Aug 9. Erratum in: Arch Neurol. 2011 Feb;68(2):159. PMID: 20697030, DOI: 10.1001/archneurol.2010.201.
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Ann N Y Acad Sci. 2010 Oct; 1207:58-70. PMID: 20955427, DOI: 10.1111/j.1749-6632.2010.05786.x.
Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H 3rd, Kryscio RJ, Lin Y, Barrett E, Head E. J Alzheimers Dis. 2010 Sep 28; 22(1):135-50. PMID: 20847439, DOI: 10.3233/JAD-2010-100639.
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer’s disease. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PLoS One. 2010 Sep 8; 5(9):e12538. PMID: 20838618, DOI: 10.1371/journal.pone.0012538.
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Neurobiol Dis. 2010 Sep; 39(3):301-10. Epub 2010 May 6. PMID: 20451612, DOI: 10.1016/j.nbd.2010.04.014.
Synergistic effects of long-term antioxidant diet and behavioral enrichment on β-amyloid load and non-amyloidogenic processing in aged canines. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. J Neurosci. 2010 Jul 21; 30(29):9831-9. PMID: 20660265, DOI: 10.1523/JNEUROSCI.6194-09.2010.
Systemic mitochondrial dysfunction and the etiology of Alzheimer’s disease and down syndrome dementia. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. J Alzheimers Dis. 2010 Jun 3; 20 Suppl 2(0 2):S293-310. PMID: 20463402, DOI: 10.3233/JAD-2010-100351.
Amyloid-β peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. J Alzheimers Dis. 2010 Apr 1; 20(2):637-46. PMID: 20164551, DOI: 10.3233/JAD-2010-1397.
Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. J Neural Transm (Vienna). 2010 Feb; 117(2):227-39. Epub 2009 Dec 10. PMID: 20012109, DOI: 10.1007/s00702-009-0350-6.
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Exp Gerontol. 2009 Dec; 44(12):752-9. Epub 2009 Sep 6. PMID: 19735717, DOI: 10.1016/j.exger.2009.08.012.
Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. Exp Neurol. 2009 Nov; 220(1):171-6. Epub 2009 Aug 22. PMID: 19703441, DOI: 10.1016/j.expneurol.2009.08.014.
Nutrition, brain aging, and neurodegeneration. Joseph J, Cole G, Head E, Ingram D. J Neurosci. 2009 Oct 14; 29(41):12795-801. PMID: 19828791, DOI: 10.1523/JNEUROSCI.3520-09.2009.
A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head. E Acta Neuropathol. 2009 Oct; 118(4):505-17. Epub 2009 Apr 10. PMID: 19360426, DOI: 10.1007/s00401-009-0530-3.
Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Christie LA, Opii WO, Head E. Age (Dordr). 2009 Sep; 31(3):211-20. Epub 2008 Jun 22. PMID: 19714491, DOI: 10.1007/s11357-008-9063-2.
Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction. Tomic JL, Pensalfini A, Head E, Glabe CG. Neurobiol Dis. 2009 Sep; 35(3):352-8. Epub 2009 Jun 10. PMID: 19523517, DOI: 10.1016/j.nbd.2009.05.024.
Synaptic proteins, neuropathology and cognitive status in the oldest-old. Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. Neurobiol Aging. 2009 Jul; 30(7):1125-34. Epub 2007 Nov 14. PMID: 18006193, DOI: 10.1016/j.neurobiolaging.2007.10.001.
Immunotherapy in a natural model of Aβ pathogenesis: the aging beagle. Vasilevko V, Head E. CNS Neurol Disord Drug Targets. 2009 Apr; 8(2):98-113. PMID: 19355931, DOI: 10.2174/187152709787847333.
Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Head E. Neurochem Res. 2009 Apr; 34(4):670-8. Epub 2008 Aug 6. PMID: 18683046, DOI: 10.1007/s11064-008-9808-4.
APOE ε2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Berlau DJ, Corrada MM, Head E, Kawas CH. Neurology. 2009 Mar 3; 72(9):829-34. PMID: 19255410, DOI: 10.1212/01.wnl.0000343853.00346.a4.
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. J Biol Chem. 2009 Feb 13; 284(7):4230-7. Epub 2008 Dec 18. PMID: 19098006, DOI: 10.1074/jbc.M808591200.
Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer’s disease. Kumasaka DK, Galvan V, Head E, Rohn TT. Int J Physiol Pathophysiol Pharmacol. 2009 Jan 12; 1(1):48-56. PMID: 20411026, Link: IJPPP901001.
Caspases as therapeutic targets in Alzheimer’s disease: is it time to “cut” to the chase? Rohn TT, Head E. Int J Clin Exp Pathol. 2009; 2(2):108-18. Epub 2008 Jun 10. PMID: 19079646, Link: IJCEP806003.
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. Cotman CW, Head E. J Alzheimers Dis. 2008 Dec; 15(4):685-707. PMID: 19096165, DOI: 10.3233/jad-2008-15413.
Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. J Comp Neurol. 2008 Nov 10; 511(2):257-70. PMID: 18792072, DOI: 10.1002/cne.21821.
Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15605-10. Epub 2008 Oct 1. PMID: 18832152, DOI: 10.1073/pnas.0806883105.
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J. J Cell Biochem. 2008 Jul 1; 104(4):1232-43. PMID: 18260126, DOI: 10.1002/jcb.21701.
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine – a novel immunotherapeutic strategy. Movsesyan N, Ghochikyan A, Mkrtichyan M, Petrushina I, Davtyan H, Olkhanud PB, Head E, Biragyn A, Cribbs DH, Agadjanyan MG. PLoS One. 2008 May 7; 3(5):e2124. PMID: 18461171, DOI: 10.1371/journal.pone.0002124.
A two-year study with fibrillar β-amyloid (Aβ) immunization in aged canines: effects on cognitive function and brain Aβ. Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. J Neurosci. 2008 Apr 2; 28(14):3555-66. PMID: 18385314, DOI: 10.1523/JNEUROSCI.0208-08.2008.
Lack of pathology in a triple transgenic mouse model of Alzheimer’s disease after overexpression of the anti-apoptotic protein Bcl-2. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. J Neurosci. 2008 Mar 19; 28(12):3051-9. PMID: 18354008, DOI: 10.1523/JNEUROSCI.5620-07.2008.
Neuroimaging of individuals with Down’s syndrome at-risk for dementia: evidence for possible compensatory events. Haier RJ, Head K, Head E, Lott IT. Neuroimage. 2008 Feb 1; 39(3):1324-32. Epub 2007 Oct 12. PMID: 18006337, DOI: 10.1016/j.neuroimage.2007.09.064.
Caspase activation in Alzheimer’s disease: early to rise and late to bed. Rohn TT, Head E. Rev Neurosci. 2008; 19(6):383-93. PMID: 19317178, DOI: 10.1515/revneuro.2008.19.6.383.
Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. Head E, Rofina J, Zicker S. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):167-78, vi. PMID: 18249248, DOI: 10.1016/j.cvsm.2007.10.002.
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurobiol Aging. 2008 Jan; 29(1):39-50. Epub 2006 Nov 7. PMID: 17092609, DOI: 10.1016/j.neurobiolaging.2006.09.018.
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer’s disease. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Neurobiol Aging. 2008 Jan; 29(1):51-70. Epub 2006 Oct 20. PMID: 17055614, DOI: 10.1016/j.neurobiolaging.2006.09.012.

Alzheimer’s disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Aβ species in amyloid precursor protein transgenic mice. Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. J Neurosci. 2007 Nov 14; 27(46):12721-31. PMID: 18003852, DOI: 10.1523/JNEUROSCI.3201-07.2007.

Cognitive dysfunction and the neurobiology of ageing in cats. Gunn-Moore D, Moffat K, Christie LA, Head E. J Small Anim Pract. 2007 Oct; 48(10):546-53. Epub 2007 Jul 6. PMID: 17617164, DOI: 10.1111/j.1748-5827.2007.00386.x.
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E. Neurobiol Aging. 2007 Oct; 28(10):1493-506. Epub 2006 Aug 9. PMID: 16904243, DOI: 10.1016/j.neurobiolaging.2006.06.023.
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Mol Neurodegener. 2007 Sep 26; 2:18. PMID: 17897471, DOI: 10.1186/1750-1326-2-18.
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. Epub 2007 Jun 22. PMID: 17587610, DOI: 10.1016/j.nlm.2007.05.001.
Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E ε2/ε2 genotype. Berlau DJ, Kahle-Wrobleski K, Head E, Goodus M, Kim R, Kawas C. Arch Neurol. 2007 Aug; 64(8):1193-6. PMID: 17698712, DOI: 10.1001/archneur.64.8.1193.
Radiotracers for a multi-target approach to the diagnosis of Alzheimer’s disease. Mukherjee J, Head E, Pichika R, Easwaramoorthy B, Collins D, Chen I, Wang CS, Saigal N, Trinidad P, Kim K, Nguyen VL. J Label Compd Radiopharm. 2007 Jul 30; 50(5-6):375-379. DOI: 10.1002/jlcr.1266.
Beta-amyloid, oxidative stress and down syndrome. Lott IT, Head E, Doran E, Busciglio J. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. PMID: 17168651, DOI: 10.2174/156720506779025305.
BioVision: an application for the automated image analysis of histological sections. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. Neurobiol Aging. 2006 Oct; 27(10):1462-76. Epub 2005 Nov 4. PMID: 16271803, DOI: 10.1016/j.neurobiolaging.2005.08.023.
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. Epub 2006 Apr 17. PMID: 16616528, DOI: 10.1016/j.nlm.2006.02.005.
Neuroprotective effects of cognitive enrichment. Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Ageing Res Rev. 2006 Aug; 5(3):354-69. Epub 2006 Sep 1. PMID: 16949888, DOI: 10.1016/j.arr.2006.04.004.
Relapsing polychondritis with features of dementia with Lewy bodies. Head E, Starr A, Kim RC, Parachikova A, Lopez GE, Dick M, Cribbs DH. Acta Neuropathol. 2006 Aug; 112(2):217-25. Epub 2006 Jul 11. PMID: 16832629, DOI: 10.1007/s00401-006-0098-0.
Ageing changes in cat brains demonstrated by β-amyloid and AT8-immunoreactive phosphorylated tau deposits. Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ. J Feline Med Surg. 2006 Aug; 8(4):234-42. Epub 2006 Apr 17. PMID: 16603401, DOI: 10.1016/j.jfms.2006.01.003.
Immunization with fibrillar Aβ1-42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Vaccine. 2006 Apr 5; 24(15):2824-34. Epub 2006 Jan 19. PMID: 16460841, DOI: 10.1016/j.vaccine.2005.12.058.
Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Neuroimage. 2006 Jan 1; 29(1):234-44. Epub 2005 Nov 7. PMID: 16275022, DOI: 10.1016/j.neuroimage.2005.07.043.
Nutritional management of brain aging in dogs. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. J Am Vet Med Assoc. 2005 Sep 1; 227(5):722-8. PMID: 16178393, DOI: 10.2460/javma.2005.227.722.
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and α-synuclein pathology. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Acta Neuropathol. 2005 Aug; 110(2):135-44. Epub 2005 Jun 29. PMID: 15986225, DOI: 10.1007/s00401-005-1027-3.
β-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Neurobiol Aging. 2005 May; 26(5):749-63. PMID: 15708450, DOI: 10.1016/j.neurobiolaging.2004.06.015.
ets-2 promotes the activation of a mitochondrial death pathway in Down’s syndrome neurons. Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. J Neurosci. 2005 Mar 2; 25(9):2295-303. PMID: 15745955, DOI: 10.1523/JNEUROSCI.5107-04.2005.
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Age (Dordr). 2005 Mar; 27(1):27-37. Epub 2005 May 2. PMID: 23598601, DOI: 10.1007/s11357-005-4001-z.
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. PMID: 15795055, DOI: 10.1016/j.pnpbp.2004.12.011.
Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):443-53. PMID: 15795053, DOI: 10.1016/j.pnpbp.2004.12.009.
A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Su MY, Tapp PD, Vu L, Chen YF, Chu Y, Muggenburg B, Chiou JY, Chen C, Wang J, Bracco C, Head E. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):389-97. PMID: 15795047, DOI: 10.1016/j.pnpbp.2004.12.005.
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. PMID: 15795044, DOI: 10.1016/j.pnpbp.2004.12.002.
Alzheimer disease and Down syndrome: factors in pathogenesis. Lott IT, Head E. Neurobiol Aging. 2005 Mar; 26(3):383-9. PMID: 15639317, DOI: 10.1016/j.neurobiolaging.2004.08.005.
Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Neurobiol Aging. 2005 Jan; 26(1):77-90. PMID: 15585348, DOI: 10.1016/j.neurobiolaging.2004.02.014.
The use of dietary antioxidants and mitochondrial co-factors to promote successful aging. Head E, Cotman CW, Zicker SC, Milgram NW. Curr Top Nutraceutical Res. 2005; 3(2):85-94.
Frontal lobe volume, function, and β-amyloid pathology in a canine model of aging. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. J Neurosci. 2004 Sep 22; 24(38):8205-13. PMID: 15385603, DOI: 10.1523/JNEUROSCI.1339-04.2004.
Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Behav Brain Res. 2004 Aug 12; 153(1):199-210. PMID: 15219721, DOI: 10.1016/j.bbr.2003.12.003.
Isolated executive impairment and associated frontal neuropathology. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Dement Geriatr Cogn Disord. 2004 Jun 10; 17(4):360-7. PMID: 15178954, DOI: 10.1159/000078183.
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Exp Gerontol. 2004 May; 39(5):753-65. PMID: 15130670, DOI: 10.1016/j.exger.2004.01.007.
Down syndrome and beta-amyloid deposition. Head E, Lott IT. Curr Opin Neurol. 2004 Apr; 17(2):95-100. PMID: 15021233, DOI: 10.1097/00019052-200404000-00003.
Nutraceuticals, aging, and cognitive dysfunction. Head E, Zicker SC. Vet Clin North Am Small Anim Pract. 2004 Jan; 34(1):217-28. PMID: 15032129, DOI: 10.1016/j.cvsm.2003.09.007.
Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. Neurology. 2003 Dec 23; 61(12):1673-9. PMID: 14694028, DOI: 10.1212/01.wnl.0000098935.36984.25.
Generation and characterization of the humoral immune response to DNA immunization with a chimeric β-amyloid-interleukin-4 minigene. Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. Eur J Immunol. 2003 Dec; 33(12):3232-41. PMID: 14635031, DOI: 10.1002/eji.200324000.
Response latency in Canis familiaris: mental ability or mental strategy? Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Behav Neurosci. 2003 Oct; 117(5):1066-75. PMID: 14570555, DOI: 10.1037/0735-7044.117.5.1066.
Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. J Neuropathol Exp Neurol. 2003 Sep; 62(9):917-26. PMID: 14533781, DOI: 10.1093/jnen/62.9.917.
Locomotor activity rhythms in dogs vary with age and cognitive status. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Behav Neurosci. 2003 Aug; 117(4):813-24. PMID: 12931965, DOI: 10.1037/0735-7044.117.4.813.
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Science. 2003 Apr 18; 300(5618):486-9. PMID: 12702875, DOI: 10.1126/science.1079469.
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Learn Mem. 2003 Jan-Feb; 10(1):64-73. PMID: 12551965, DOI: 10.1101/lm.54403.
Caspase activation in the Alzheimer’s disease brain: tortuous and torturous. Rohn TT, Rissman RA, Head E, Cotman CW. Drug News Perspect. 2002 Nov; 15(9):549-557. PMID: 12677194, DOI: 10.1358/dnp.2002.15.9.740233, Link to original.
Caspase-9 activation and caspase cleavage of tau in the Alzheimer’s disease brain. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Neurobiol Dis. 2002 Nov; 11(2):341-54. PMID: 12505426, DOI: 10.1006/nbdi.2002.0549.
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Ann N Y Acad Sci. 2002 Nov; 977:45-64. PMID: 12480733, DOI: 10.1111/j.1749-6632.2002.tb04798.x.
Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. Neurosci Biobehav Rev. 2002 Oct; 26(6):679-95. PMID: 12479842, DOI: 10.1016/s0149-7634(02)00039-8.
Neurobiological basis for cognitive dysfunction in aging dogs: identifying strategies to promote successful aging. Head E. Gerontology: Prolonging Health through Nutrition (2001 Purina Forum, Supplement to Compendium on Continuing Education for Practicing Veterinarian), 2002 Oct; 24(9A):35-9.
β-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Neurosci Lett. 2002 Sep 13; 330(1):99-103. PMID: 12213643, DOI: 10.1016/s0304-3940(02)00705-x.
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. PMID: 12392784, DOI: 10.1016/s0197-4580(02)00073-8.
Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. Neurobiol Aging. 2002 Sep-Oct; 23(5):737-45. PMID: 12392778, DOI: 10.1016/s0197-4580(02)00020-9.
Oxidative damage increases with age in a canine model of human brain aging. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. J Neurochem. 2002 Jul; 82(2):375-81. PMID: 12124438, DOI: 10.1046/j.1471-4159.2002.00969.x.
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Behav Neurosci. 2002 Jun; 116(3):443-54. PMID: 12049325, DOI: 0735-7044.116.3.443.
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. PMID: 11854529, DOI: 10.1073/pnas.261709299.
Insights into Aβ and presenilin from a canine model of human brain aging. Head E, Torp R. Neurobiol Dis. 2002 Feb; 9(1):1-10. PMID: 11848680, DOI: 10.1006/nbdi.2002.0476.
Activation of caspase-8 in the Alzheimer’s disease brain. Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. Neurobiol Dis. 2001 Dec; 8(6):1006-16. PMID: 11741396, DOI: 10.1006/nbdi.2001.0449.
Oxidation of Aβ and plaque biogenesis in Alzheimer’s disease and Down syndrome. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Neurobiol Dis. 2001 Oct; 8(5):792-806. PMID: 11592849, DOI: 10.1006/nbdi.2001.0431.
Down syndrome and Alzheimer’s disease: a link between development and aging. Lott IT, Head E. Ment Retard Dev Disabil Res Rev. 2001 Aug; 7(3):172-8. PMID: 11553933, DOI: 10.1002/mrdd.1025.
Age dependent cognitive dysfunction in canines: dietary intervention. Milgram NW, Head E, Cotman CW, Zicker SC. Proceedings of the Third International Congress on Veterinary Behavioural Medicine, Vancouver BC. 2001 Aug 7-8; Eds: Overall KL, Mills DS, Heath SE, Horwitz D, Universities Federation for Animal Welfare, Wheathampstead, UK, pp 53-7.
Brain aging in dogs: parallels with human brain aging and Alzheimer’s disease. Head E. Vet Ther. 2001 Summer; 2(3):247-60. PMID: 19746668.
Complement association with neurons and β-amyloid deposition in the brains of aged individuals with Down syndrome. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Neurobiol Dis. 2001 Apr; 8(2):252-65. PMID: 11300721, DOI: 10.1006/nbdi.2000.0380.
Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer’s disease. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. Am J Pathol. 2001 Jan; 158(1):189-98. PMID: 11141492, DOI: 10.1016/S0002-9440(10)63957-0.
Ultrastructural analyses of β-amyloid in the aged dog brain: neuronal β-amyloid is localized to the plasma membrane. Torp R, Head E, Cotman CW. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):801-10. PMID: 11191714, DOI: 10.1016/s0278-5846(00)00107-x.
Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Head E, Thornton PL, Tong L, Cotman CW. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. PMID: 11191712, DOI: 10.1016/s0278-5846(00)00105-6.
Development of a protocol for studying object recognition memory in the dog. Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):693-707. PMID: 11191709, DOI: 10.1016/s0278-5846(00)00102-0.
Canine cognition, aging and neuropathology. Introduction. Head E, Cotman CW, Milgram NW. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. PMID: 11191707, DOI: 10.1016/s0278-5846(00)00100-7.
Topography, histology, and seminology in dementia. Johnson JK, Head E, Kim R, Starr A, Cotman CW. Arch Neurol. 2000 Jun; 57(6):899-900. PMID: 10867791, Link to original.
Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. Exp Neurol. 2000 May; 163(1):111-22. PMID: 10785449, DOI: 10.1006/exnr.2000.7359.
Ultrastructural evidence of fibrillar β-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Neuroscience. 2000 Mar; 96(3):495-506. PMID: 10717430, DOI: 10.1016/s0306-4522(99)00568-0.
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Behav Brain Res. 2000 Feb; 108(1):47-56. PMID: 10680756, DOI: 10.1016/s0166-4328(99)00132-1.
Region-specific age at onset of β-amyloid in dogs. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. PMID: 10794853, DOI: 10.1016/s0197-4580(00)00093-2.
Clinical and pathological evidence for a frontal variant of Alzheimer disease. Johnson JK, Head E, Kim R, Starr A, Cotman CW. Arch Neurol. 1999 Oct; 56(10):1233-9. PMID: 10520939, DOI: 10.1001/archneur.56.10.1233.
The presence of isoaspartic acid in β-amyloid plaques indicates plaque age. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. Exp Neurol. 1999 Jun; 157(2):277-88. PMID: 10364440, DOI: 10.1006/exnr.1999.7058.
Landmark discrimination learning in the dog. Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Learn Mem. 1999 Jan-Feb; 6(1):54-61. PMID: 0355524, DOI: 10.1101/lm.6.1.54.
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. PMID: 9880050, DOI: 10.1016/s0197-4580(98)00081-5.
Visual-discrimination learning ability and β-amyloid accumulation in the dog. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. PMID: 9880044, DOI: 10.1016/s0197-4580(98)00084-0.
Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures. Ikeda-Douglas CJ, Head E, Holsinger RM, Tremblay L, Racine R, Milgram NW. Epilepsy Res. 1998 Jul; 31(2):143-52. PMID: 9714506, DOI: 10.1016/s0920-1211(98)00028-x.
Therapeutic actions of L-deprenyl in dogs: a model of human brain aging. Ruehl WW, Neilson J, Hart B, Head E, Bruyette DS, Cummings BJ. Adv Pharmacol. 1998;42:316-9. PMID: 9327904, DOI: 10.1016/s1054-3589(08)60753-x.
Effects of extended electrical kindling on exploratory behavior and spatial learning. Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RM, Head E, Michael M, Racine RJ, Milgram NW. Behav Brain Res. 1997 Dec; 89(1-2):179-90. PMID: 9475625, DOI: 10.1016/s0166-4328(97)00059-4.
The progression of β-amyloid deposition in the frontal cortex of the aged canine. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. Brain Res. 1997 Nov 7; 774(1-2):35-43. PMID: 9452189, DOI: 10.1016/s0006-8993(97)81684-8.
Open field activity and human interaction as a function of age and breed in dogs. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Physiol Behav. 1997 Nov; 62(5):963-71. PMID: 9333188 DOI: 10.1016/s0031-9384(97)00198-4.
Diffuse plaques contain C-terminal Aβ42 and not Aβ40: evidence from cats and dogs. Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Neurobiol Aging. 1996 Jul-Aug; 17(4):653-9. PMID: 8832640, DOI: 10.1016/0197-4580(96)00062-0.
β-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. PMID: 8661247, DOI: 10.1006/nlme.1996.0039.
The effects of L-deprenyl on spatial short term memory in young and aged dogs. Head E, Hartley J, Kameka AM, Mehta R, Ivy GO, Ruehl WW, Milgram NW. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Apr; 20(3):515-30. PMID: 8771606, DOI: 10.1016/0278-5846(96)00014-0.
The canine as an animal model of human aging and dementia. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. PMID: 8744407, DOI: 10.1016/0197-4580(95)02060-8.
Spatial learning and memory as a function of age in the dog. Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. Behav Neurosci. 1995 Oct; 109(5):851-8. PMID: 8554710, DOI: 10.1037//0735-7044.109.5.851.
Effects of chronic oral administration of L-deprenyl in the dog. Milgram NW, Ivy GO, Murphy MP, Head E, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Boulton AA. Pharmacol Biochem Behav. 1995 Jun-Jul; 51(2-3):421-8. PMID: 7667363, DOI: 10.1016/0091-3057(94)00417-h.
Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression. Milgram NW, Michael M, Cammisuli S, Head E, Ferbinteanu J, Reid C, Murphy MP, Racine R. Brain Res. 1995 Jan 23; 670(1):112-20. PMID: 7719710, DOI: 10.1016/0006-8993(94)01277-o.
Effects of L-deprenyl on manifestations of aging in the rat and dog. Ivy GO, Rick JT, Murphy MP, Head E, Reid C, Milgram NW. Ann N Y Acad Sci. 1994 Jun 30; 717:45-59. PMID: 8030851, DOI: 10.1111/j.1749-6632.1994.tb12072.x.
Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Milgram NW, Head E, Weiner E, Thomas E. Behav Neurosci. 1994 Feb; 108(1):57-68. PMID: 8192851, DOI: 10.1037//0735-7044.108.1.57.
(-)deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Carrillo MC, Ivy GO, Milgram NW, Head E, Wu P, Kitani K. Life Sci. 1994; 54(20):1483-9. PMID: 8190023, DOI: 10.1016/0024-3205(94)90015-9.
The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog. Milgram NW, Ivy GO, Head E, Murphy MP, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Paterson IA, et al. Neurochem Res. 1993 Dec; 18(12):1211-9. PMID: 8272186, DOI: 10.1007/BF00975038.
Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Head E, Milgram NW. Pharmacol Biochem Behav. 1992 Nov; 43(3):749-57. PMID: 1448469, DOI: 10.1016/0091-3057(92)90404-4.
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